A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination\nof the content of fluorinated pharmaceuticals. 19F NMR spectra were either obtained in dimethylsulfoxide-d6 or aqueous\nbuffer, using trifluoroacetic acid as internal standard. Quantification of 13 fluorine-containing pharmaceuticals spanning various\npharmacological classes was accomplished using the proposed method. The method was found to be fit for purpose (interday\nprecision 1.2% relative standard deviation) and may thus be applied for routine analysis and quality control of fluorine-containing\npharmaceuticals due to its simplicity, nondestructive samplemeasurement, reliability, and high specificity. Therefore, 19FNMRmay\nserve as a suitable analytical tool for the identification and selective determination of fluorinated pharmaceuticals used as reference\nmaterials and bulk samples.
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